Exclusively for DrWell Prescribers

GLP-1² for Cravings
A New Clinical Opportunity

Expand Your Practice. Differentiate Your Care.
As GLP-1 therapies become increasingly commoditized, differentiation becomes critical. Learn more about GLP-1² and how innovation in formulation and clinical application can position your practice for long-term success.

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The Opportunity

Help with Alcohol Use Disorder Through Biology

Alcohol use disorder (AUD) remains one of the most undertreated conditions in medicine—despite its massive clinical and economic impact.

GLP-1² introduces a novel, biology-driven approach to managing cravings and reward pathways—while DrWell provides the infrastructure to deliver it compliantly and efficiently.

FDA Pathway Update

DrWell is actively going through the process of getting GLP-1² approved for AUD via the IND (investigational new drug) pathway through the FDA. While it's currently not approved or indicated for AUD, you as the provider can legally offer this formulation, off label, without any claims of efficacy for patients you clinically assess as struggling with any craving or addiction.

Mechanism of Action

Why GLP-1²?

GLP-1 receptor activity extends beyond metabolic regulation into the central nervous system, particularly areas involved in reward and addiction.

01

Dual Agonism with Signaling Bias

Tirzepatide activates both GLP-1 and GIP receptors. Exhibits biased agonism favoring G protein signaling over β-arrestin recruitment.

02

Dopaminergic Modulation

Acts on the mesolimbic pathway to reduce alcohol-associated reward signaling and addictive behaviors.

03

Craving Reduction

Influences hypothalamic and brainstem pathways involved in appetite and compulsion.

04

Impulse Control Support

Targets the centers of the brain responsible for habit forming. May reduce compulsive alcohol-seeking behavior.

05

Metabolic Stabilization

Improves glycemic variability, reducing physiologic triggers for cravings and enhancing overall metabolic health. A dual-pathway approach that addresses both the neurological and metabolic dimensions of addiction.

Current Standard

Traditional Treatments

Traditional AUD treatments focus on distinct and separate pathways:

  • Aversion (e.g., disulfiram)
  • Opioid antagonism (e.g., naltrexone)
  • Neurotransmitter modulation (e.g., acamprosate)
The GLP-1² Difference

A Complementary Pathway

GLP-1² introduces a completely novel complementary pathway: Targeting reward biology and metabolic drivers simultaneously.

The DrWell Ecosystem

Why Offer GLP-1² Through DrWell?

GLP-1² is not just a therapy—it's a program. And delivering it effectively requires more than simply prescribing.

01

Compliant Patient Acquisition

LegitScript-supported marketing pathways. Done-for-you campaigns that drive qualified patients directly to your practice.

02

SmartConsult™ Intake & Triage

Asynchronous, compliant patient evaluations. Streamlined qualification for AUD and related indications.

03

Integrated E-Ordering

Seamless prescribing workflows with vetted pharmacy partners. Transparent pricing and supply chain reliability.

04

Subscription-Based Care Models

Build recurring revenue through structured programs. Combine GLP-1² with wellness, behavioral, or adjunct therapies.

05

50-State Ready Infrastructure

Support for asynchronous care models (state-dependent). Medical director collaboration available where required. Scale your practice nation-wide with full compliance.

Your Patients

Who This Is For

GLP-1² may be appropriate for patients who:

  • Experience persistent alcohol-specific or any cravings or binge patterns
  • Have not achieved success with traditional therapies
  • Would benefit from a biologically targeted approach
  • May also have metabolic comorbidities (e.g., overweight, insulin resistance)
For Providers

Why Offer It

By adding GLP-1² to your practice, you can:

  • Differentiate your practice in a crowded GLP-1 market
  • Help patients with addictive behaviors such as smoking, vaping or other vices
  • Increase patient lifetime value through subscription-based programs
  • Leverage DrWell's compliant growth engine instead of DIY marketing